Figure 2.

Association of circ‐VRK1 relative expression with clinicopathological features in breast cancer patients. Correlation between circ‐VRK1 and pathology grade was presented (P = .036) (B). Circ‐VRK1 was negatively correlated with tumour size (C), T stage (D), N stage (E) and TNM stage (F). There is no association of circ‐VRK1 with age (A), ER (G), PR (H) or HER2 (I). The Kruskal‐Wallis H rank sum test and the Wilcoxon rank sum test were used to determine the difference in circVRK1 expression in breast cancer patients with different clinicopathological features. And the Spearman test was performed to observe the correlation of circ‐VRK1 with age and tumour size in breast cancer patients. P < .05 was considered significant. Circ‐VRK1, Circular RNA VRK serine/threonine kinase 1; ER, estrogen receptor; HER 2, human epidermal growth factor receptor 2; PR, progesterone receptor; TNM, TNM Classification of Malignant Tumours