Table 3.
Multivariate Cox's proportional hazard regression analysis of factors affecting OS
| Multivariate Cox's regression model | ||||
|---|---|---|---|---|
| P value | HR | 95% CI | ||
| Lower | Higher | |||
| Circ‐VRK1 (high vs low) | .031 | 0.481 | 0.248 | 0.934 |
| Age (≥60 y vs <60 y) | .259 | 1.558 | 0.722 | 3.360 |
| Pathological grade (G3 vs G1/2) | .016 | 3.431 | 1.263 | 9.321 |
| Tumour size (≥3 cm vs <3 cm) | .174 | 2.226 | 0.702 | 7.058 |
| T stage (T2/T3 vs T1) | .672 | 1.358 | 0.329 | 5.599 |
| N stage (N1/N2/N3 vs N0) | .574 | 1.359 | 0.467 | 3.959 |
| TNM stage (III vs II/I) | <.001 | 5.555 | 2.156 | 14.312 |
| ER status (positive vs negative) | .614 | 1.258 | 0.515 | 3.071 |
| PR status (positive vs negative) | .087 | 0.443 | 0.175 | 1.125 |
| HER2 status (positive vs negative) | .151 | 1.623 | 0.838 | 3.145 |
Data were presented as P value, HR (hazards ratio) and 95% CI (confidence interval). P < .05 was considered significant.
Abbreviations: ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; OS, overall survival; PR, progesterone receptor.