Table 2.
Baseline characteristics of patients with AADA and hypoxemia at 24 h after surgery: post-PSM
| Patients’ Characteristics | Control (N = 94) | iNO treatment (N = 40) | p-value |
|---|---|---|---|
| Age, y | 50.5 ± 11.2 | 49.9 ± 11.2 | 0.763 |
| Men | 75 (79.8) | 31 (77.5) | 0.766 |
| BMI | 26.1(24.9, 28.6) | 26.5(24.5, 27.7) | 0.719 |
| Comorbidity | |||
| Hypertension | 65 (69.1) | 32 (80.0) | 0.199 |
| Diabetes | 1 (1.1) | 2 (5.0) | 0.159 |
| COPD | 2 (2.1) | 1 (2.5) | 0.894 |
| Hepatic insufficiency | 1 (1.1) | 1 (2.5) | 0.530 |
| Renal insufficiency | 20 (21.3) | 12 (30.0) | 0.163 |
| Cerebrovascular event | 2 (2.1) | 2 (5.0) | 0.734 |
| Tamponade | 17 (18.1) | 9 (22.5) | 0.554 |
| Myocardial infarction | 8 (8.5) | 2 (5.0) | 0.479 |
| Marfan Syndrome | 3 (3.2) | 3 (7.5) | 0.270 |
| Smoking | 23 (24.5) | 8 (20) | 0.575 |
| Laboratory test | |||
| Leucocyte (109/L) | 11.8 ± 3.8 | 13.0 ± 3.3 | 0.086 |
| Hemoglobin (g/L) | 134.0(124.0, 143.0) | 137.5(124.8, 150.3) | 0.652 |
| Platelet (109/L) | 162.0 (127.0, 212.0) | 161.5(140.5, 200.0) | 0.726 |
| ALT (U/L) | 27.0(20.0, 39.5) | 30.5(19.0, 41.4) | 0.934 |
| Creatinine (μmol/L) | 82.0(66.5, 108.2) | 89.5(70.2, 132.0) | 0.256 |
| Troponin I (ng/ml) | 0.02(0.01, 0.07) | 0.02(0.01, 0.08) | 0.489 |
| PaO2 (mmHg) | 83.5(70, 99) | 80(67.7, 109.2) | 0.132 |
| Surgical procedure | |||
| Total arch replacement | 89 (94.7) | 38 (95.0) | 1.000 |
| Hemi arch replacement | 5 (5.3) | 2 (5.0) | 1.000 |
| Concomitant CABG | 9 (9.6) | 2 (5.0) | 0.377 |
| CPB | |||
| CPB time (min) | 167.5(149.0, 183.0) | 162.5(147.0, 191.5) | 0.808 |
| ACC time (min) | 97.5(84.0, 109.3) | 96.0(87.3, 117.3) | 0.569 |
| DHCA time (min) | 26.0(20.8, 30.0) | 24.0 (19.0, 28.0) | 0.143 |
| Minimum temperature in CPB (°C) | 22.1(22.1, 24.3) | 22.1(21.5, 23.5) | 0.129 |
| PaO2/FiO2 ratio meet hypoxemia criteria | 109.0(85.2, 130.1) | 95.0(82.9, 127.1) | 0.524 |
AADA Acute type A aortic dissection, PSM Propensity score-matching, iNO Inhaled nitric oxide, BMI Body mass index, COPD Chronic obstructive pulmonary disease, ALT Alanine transaminase, CPB Cardiopulmonary bypass, ACC Aortic cross-clamp, DHCA Deep hypothermic circulatory arrest, PaO2 Partial pressure of oxygen, FiO2 Fraction of inspired oxygen