Figure 1.

Overview of the PharmCAT tool. Sample VCF file is provided by the user. Allele definitions and recommendations (extracted from PGx guidelines) are combined with additional curated information such as notes, caveats, and warnings. The NamedAlleleMatcher and Reporter are core components of PharmCAT. CYP2D6 calls are done externally and passed to the Reporter for the Final Report output. CYP, cytochrome P450. VCF, variant call format. [Colour figure can be viewed at https://www.wileyonlinelibrary.com]