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. 2020 Jan 23;18:36. doi: 10.1186/s12967-020-02221-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Effect of IL-1β, TNF-α, TGF-β and IL-17 treatment on the expression of IL19, IL20, IL24 and their receptors. The mRNA expression of IL19, IL20, IL24, IL20RA, IL20RB and IL22RA was determined by real-time RT-PCR in comparison with RPLP0 as internal control. Heat maps illustrate the mean fold change in relative expression of the examined genes after different treatments in FHs74Int cells (a), pdMFs (b) and PBMCs of children with CD (f) compared to vehicle controls (n = 6). Graphs of individual measurements can be found in Additional files 3, 4, 5, 6, 7. The mRNA expression of IL19 (c), IL20 (d) and IL24 (e) was determined in the PBMCs of 8–8 children with CD and controls, respectively. Results are presented as mean ± SD. ND: not detectable; *p < 0.05 vs. control (Mann–Whitney U-test)