Table 1.
Summary of the clinical significances of some representative circRNAs in common cancers
| Cancer type | Level | circRNA | Clinical significances | Reference |
|---|---|---|---|---|
| Gastric cancer | Down | hsa_circ_002059 | Diagnostic biomarker | 5 |
| circ_LARP4 | Suppressive effect and diagnosis | 39 | ||
| hsa_circ_0000190 | Non‐invasive diagnostic biomarker | 40 | ||
| hsa_circ_0000096 | Diagnostic biomarker | 74 | ||
| Up | circ_SFNBT2 | Treatment target | 41 | |
| circ_PVT1 | Proliferative effect and prognostic biomarker | 42 | ||
| Hepatocellular carcinoma | Up | circRNA_104075 | Diagnostic and treatment biomarker | 43 |
| circRNA_100338 | Diagnostic biomarker and therapeutic target | 44 | ||
| Down | circ_MTO1 | Therapeutic target and prognostic predictor | 45 | |
| circ_ZKSCAN1 | Diagnostic biomarker | 46 | ||
| Colorectal cancer | Up | hsa_circ_0136666 | Treatment target | 47 |
| Down | hsa_circ_0000523 | ‐ | 48 | |
| Lung cancer | Down | hsa_circ_0006427 | ‐ | 49 |
| Up | circRNA_100876 | Prognostic biomarker and therapeutic target | 50 | |
| circ_ABCB10 | Diagnostic biomarker and therapeutic target | 51 | ||
| Breast cancer | Down | circASS1 | ‐ | 52 |
| Up | circAGFG1 | Diagnostic biomarker and therapeutic target | 53 | |
| circEPSTI1 | Independent prognostic biomarker | 54 | ||
| Bladder cancer | Down | circFNDC3B | ‐ | 55 |
| Up | circTFRC | Diagnostic biomarker | 56 | |
| Esophageal cancer | Up | circRNA_100876 | ‐ | 57 |
| Down | circ_DLG1 | Diagnostic biomarker | 58 |