Fig. 2. Predicted structure of the GLP-1R/GLP-1[A^u]² complex compared to the cryo-EM structure of the GLP-1R/GLP-1 complex. (a and b) GLP-1 (in orange) in the GLP-1R TMD and an enlarged image (b) of the N-terminal part (extracted from the cryo-EM structure of the GLP-1R/GLP-1 complex (PDB ; 5VAI));21 (c and d) predicted structure of GLP-1[A^u]² (3) (in blue with Ala^u2 in green) in the GLP-1R TMD and an enlarged image (d) of the N-terminal part.