Fig. 7. GLP-1R biased signalling. Signal bias calculated from the data shown in Fig. 6a, expressed relative to GLP-1–NH2 (2), determined using a modified form of the operational model (see Methods for details†), and 1-way randomised block ANOVA with Tukey's test of difference between Log R values for cAMP vs. β-arrestin-2 responses for each ligand.
