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. 2020 Jan 20;8:e8422. doi: 10.7717/peerj.8422

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©2020 Cai et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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Generic PPI (A) and the top 10 genes (B) involved in that PPI. TF-gene interactions (C) and the top 10 genes (D)involved in these interactions. Genes are shown as pink circles, and transcription factors are shown as blue squares. Gene-miRNA interactome (E) and the top 10 genes (F) involved in these interactions. Genes are shown as pink circles and miRNAs are shown as blue squares. TF-miRNA coregulatory interactions (G) and the top 10 genes (H) involved in these interactions. Genes are circles. miRNAs are shown as blue diamonds. TFs are shown as green diamonds. The distribution (I) and frequency (J) of the top 10 genes in these four interaction networks mentioned above are shown.