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Effects of sepsis on AHR and inflammatory factors. During sepsis, the activation of NF-κB increases the expression of inflammatory factors IL-1β and IL-10 in LPS-stimulated inflammatory macrophages, and the expression of AHR is upregulated through the NF-κB pathway. Concurrently, the activation of AHR can enhance the phosphorylation of SRC; then, p-SRC upregulates STAT3 phosphorylation, and p-STAT3 further positively regulates the production of IL-10 by macrophages.
