Table 5.
Outcomes and complications by study arm.
| Not on Anticoagulants n = 189 | Not Reversed n = 84 | Reversed n = 186 | p | |
|---|---|---|---|---|
| ICU LOS Median (IQR) | 3 (3, 5) | 4 (3, 7) | 4 (3, 9) | 0.50 |
| Hospital LOS Median (IQR) | 5 (4, 7) | 4 (4, 5) | 6 (4, 9) | <0.001a |
| Complications | ||||
| PE | 2% (3) | 0 | 0 | 0.22 |
| Return to ICU | 6% (11) | 2% (2) | 1% (1) | 0.007b |
| Pneumonia | 2% (3) | 0 | 4% (7) | 0.12 |
| DVT | 4% (7) | 1% (1) | 2% (4) | 0.59 |
| Stroke or CVA | 2% (3) | 0 | 1% (1) | 0.53 |
| MI | 1% (2) | 0 | 0 | 0.67 |
| Wound Hematoma | 1% (2) | 1% (1) | 2% (4) | 0.78 |
| Mortality % (n) | 1% (1) | 0 | 1% (2) | >0.99 |
| Odds Ratio (CI) | 0.3 (0.1, 1.3) | 0.3 (0, 2.5) | Reference | 0.20 |
| Blood transfusions (ml) | ||||
| FFP Median (IQR) | 6231 | 513 (316, 661) | 443 (299, 620) | N/A |
| pRBC Median (IQR) | 498 (350, 700) | 570 (310, 660) | 660 (359, 761) | 0.03 |
| Platelets Median (IQR) | 456 (284) | 2631 | N/A | N/A |
| Blood Loss Median (IQR) | 100 (50, 150) | 100 (50, 150) | 100 (50, 200) | 0.70 |
Bonferroni-adjusted p = 0.025, N = number of patients, p = p-value, ICU = intensive care unit, LOS = length of stay, PE = pulmonary embolus, DVT = deep vein thrombosis, CVA = cerebrovascular accident, MI = myocardial infarction, FFP = fresh frozen plasma, RBC = packed red blood cells. 1 = Value only collected for one patient. a = All differences observed were significantly different. b = Patients not on anticoagulants were more likely than those reversed to return to ICU, no statistically significant differences observed for patients not on anticoagulants and not reversed patients, p = 0.36, or for patients not reversed and reversed, p = 0.23.