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. 2020 Jan 12;26:e919460-1–e919460-10. doi: 10.12659/MSM.919460

Figure 1.

Figure 1

AGS and MKN28 human gastric cancer cell viability was significantly inhibited by the use of splicing factor 3b subunit 1 (SF3B1) small interfering RNA (siRNA) and pladienolide B. (A) The effect of siRNA and pladienolide B on SF3B1 expression was shown by quantitative analysis. (B) The chemical structure of pladienolide B, a selective mRNA splicing inhibitor of SF3B1. (C) The cell viability AGS and MKN28 human gastric cancer cells with SF3B1 siRNA and (D) pladienolide B evaluated by the Cell Counting Kit-8 (CCK-8) assay. The experiments were performed in triplicate. The mean±SD represents the data. * p<0.05 (vs. the control group).