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. 2020 Jan 12;26:e919460-1–e919460-10. doi: 10.12659/MSM.919460

Figure 3.

Figure 3

Inhibition of splicing factor 3b subunit 1 (SF3B1) by small interfering RNA (siRNA) and pladienolide B and the expression of homeobox A10 (HOXA10) and the AKT pathway in AGS and MKN28 human gastric cancer cells. (A) List of genes in Table 1 that showed altered expressed in more than 5% of samples using data from The Cancer Genome Atlas (TCGA) gastric cancer cohort in cBioPortal. (B) HOXA10 gene structure and alternative transcripts. (C) The effect of siRNA and pladienolide B on HOXA10 mRNA/lnc-HOXA10/total HOXA10 expression shown by quantitative analysis. (D) Representative Western blot images of relative protein expression in AGS and MKN28 human gastric cancer cells. The experiments were performed in triplicate. The mean±SD represents the data. * p<0.05 (vs. the control group).