Table 1.
Genes with a percent spliced in index (PSI) rate of >2.5 times the alternative splicing events differently in gastric cancer samples.
| Splice type | Exon | Gene symbol | PSI (tumor tissue) | PSI (normal tissue) | Ratio of PSI change |
|---|---|---|---|---|---|
| Upregulation | |||||
| ES | 5 | MAGI2 | 39.1 | 2.7 | 14.48148 |
| AP | 1 | HOXC4 | 22.3 | 2.0 | 11.15 |
| AT | 5 | CLEC3A | 46.7 | 5.4 | 8.648148 |
| ES | 2 | CKMT2 | 42.2 | 5.9 | 7.152542 |
| RI | 3.2 | CLU | 32.7 | 5.7 | 5.736842 |
| AP | 1 | ALDH1L1 | 47.8 | 8.7 | 5.494253 |
| AP | 4.1 | TGFBR3 | 26.9 | 5.0 | 5.38 |
| AP | 5 | KCNN2 | 86.5 | 17.1 | 5.05848 |
| AP | 5 | COLEC11 | 42.6 | 8.9 | 4.786517 |
| ES | 2 | ZMAT1 | 54.5 | 12.6 | 4.325397 |
| AP | 2 | ISLR | 47.6 | 11.1 | 4.288288 |
| AP | 2 | ARHGAP28 | 29.0 | 6.9 | 4.202899 |
| AP | 8.1 | EPS8L1 | 45.6 | 11.0 | 4.145455 |
| AP | 10 | SH3KBP1 | 37.0 | 9.1 | 4.065934 |
| AP | 1 | PKIB | 34.8 | 8.6 | 4.046512 |
| RI | 4.2 | FAM214B | 27.0 | 6.8 | 3.970588 |
| AP | 2 | ANKMY1 | 27.8 | 7.1 | 3.915493 |
| AT | 13 | CNGB1 | 28.3 | 7.4 | 3.824324 |
| ES | 4.2: 5.1: 5.2 | ZNF707 | 27.1 | 7.1 | 3.816901 |
| AP | 1 | APOLD1 | 47.3 | 12.4 | 3.814516 |
| ES | 13 | PLCD4 | 62 | 16.3 | 3.803681 |
| AD | 1.2: 1.3: 1.4: 1.5: 1.6 | RUVBL2 | 29.5 | 7.8 | 3.782051 |
| AP | 7 | LDLRAD4 | 27.5 | 7.4 | 3.716216 |
| ES | 2.1: 2.2 | SLC25A16 | 36.6 | 10.0 | 3.66 |
| ES | 16 | SORBS1 | 46.3 | 13.0 | 3.561538 |
| AP | 5 | CDYL | 32.4 | 9.3 | 3.483871 |
| AP | 8 | CASQ1 | 71.0 | 20.6 | 3.446602 |
| ES | 6 | COL6A3 | 51.4 | 15.0 | 3.426667 |
| AP | 1 | HOXC6 | 36.0 | 10.9 | 3.302752 |
| AP | 2 | IL20RB | 35.3 | 10.9 | 3.238532 |
| AT | 4.2 | ARHGEF4 | 39.2 | 12.3 | 3.186992 |
| AP | 14 | AK5 | 42.2 | 13.3 | 3.172932 |
| AP | 1 | CCL14 | 58.9 | 18.9 | 3.116402 |
| AP | 2 | LRRC32 | 32.0 | 10.4 | 3.076923 |
| AP | 8 | PLEKHG5 | 41.5 | 13.8 | 3.007246 |
| AP | 6 | HDAC9 | 55.0 | 18.8 | 2.925532 |
| AP | 2.1 | VPS9D1 | 39.6 | 13.6 | 2.911765 |
| AP | 1 | HOXA10 | 50.2 | 17.5 | 2.868571 |
| AP | 5.1 | SUOX | 30.8 | 10.8 | 2.851852 |
| ES | 5 | PDLIM7 | 33.8 | 11.9 | 2.840336 |
| AP | 1.1 | OSBPL1A | 35.9 | 12.7 | 2.826772 |
| ES | 12: 13: 14: 15: 16: 19 | TNC | 48.2 | 17.1 | 2.818713 |
| AP | 7.1 | ANGEL1 | 39.6 | 14.2 | 2.788732 |
| AP | 5.1 | STK33 | 32.6 | 12.1 | 2.694215 |
| AT | 10.2 | MYPN | 35.2 | 13.2 | 2.666667 |
| AP | 1 | WNT2B | 43.6 | 16.4 | 2.658537 |
| AP | 2.1 | RHBDL1 | 49.5 | 18.7 | 2.647059 |
| AP | 4 | 4-Sep | 34.7 | 13.2 | 2.628788 |
| ES | 9 | ZNF667 | 38.4 | 14.7 | 2.612245 |
| AT | 8 | PPP1R1A | 35.7 | 13.7 | 2.605839 |
| ES | 3: 4: 5: 6: 7: 8: 9: 10: 11: 12: 13: 14: 15: 16: 17 | COL12A1 | 89.8 | 35.0 | 2.565714 |
| ES | 2: 3.1: 3.2 | SHROOM1 | 37.7 | 14.7 | 2.564626 |
| AP | 2 | SMAD6 | 34.5 | 13.5 | 2.555556 |
| AP | 2 | DYSF | 49.9 | 19.6 | 2.545918 |
| RI | 3.4: 3.5 | SH2B1 | 39.5 | 15.6 | 2.532051 |
| AP | 8 | DNMT3A | 35.4 | 14.1 | 2.510638 |
| Down-regulation | |||||
| AP | 2 | NRG2 | 1.8 | 22.8 | 12.66667 |
| AP | 4 | LSP1 | 4.0 | 32.5 | 8.125 |
| AP | 1 | TRAK1 | 4.5 | 28.0 | 6.222222 |
| AT | 36 | LAMB4 | 4.4 | 25.2 | 5.727273 |
| AP | 2 | KCNH5 | 6.2 | 34.2 | 5.516129 |
| AP | 7 | MLLT3 | 6.5 | 30.3 | 4.661538 |
| ES | 29: 30: 32 | KIF21A | 6.2 | 28.3 | 4.564516 |
| ES | 19 | DYSF | 11.4 | 51.7 | 4.535088 |
| ES | 24 | KIF21A | 8.6 | 35.4 | 4.116279 |
| ES | 19: 20: 21: 22 | MICAL3 | 7.1 | 27.1 | 3.816901 |
| AP | 12.1 | CHN2 | 14.9 | 55.0 | 3.691275 |
| ES | 23: 24 | TNS1 | 11.3 | 40.9 | 3.619469 |
| ES | 13: 14 | TBC1D1 | 7.9 | 28.1 | 3.556962 |
| AP | 4 | GAS7 | 10.5 | 37.3 | 3.552381 |
| ES | 16 | SVIL | 12.6 | 43.3 | 3.436508 |
| AP | 2 | RTKN | 8.7 | 29.8 | 3.425287 |
| AP | 1 | ASTN2 | 16.7 | 55.8 | 3.341317 |
| AP | 1 | SPTBN1 | 12.1 | 39.7 | 3.280992 |
| AP | 1 | ARHGEF9 | 9.0 | 29.4 | 3.266667 |
| ES | 11 | FBLN2 | 22.6 | 73.3 | 3.243363 |
| AP | 1 | RARB | 10.8 | 34.7 | 3.212963 |
| AP | 1 | PDE8B | 19.9 | 63.9 | 3.211055 |
| ES | 9 | PAPSS2 | 10.4 | 32.6 | 3.134615 |
| AT | 7.3 | TRIM73 | 12.3 | 38.4 | 3.121951 |
| AT | 3 | TMEM151B | 17.6 | 54.0 | 3.068182 |
| ES | 19 | VCL | 18.0 | 51.7 | 2.872222 |
| AT | 2 | FAM72A | 12.0 | 34.2 | 2.85 |
| AP | 2 | PLEKHG5 | 13.2 | 37.3 | 2.825758 |
| AP | 3.1 | COL18A1 | 16.0 | 44.9 | 2.80625 |
| AT | 20 | GRIK2 | 13.1 | 36.3 | 2.770992 |
| AP | 1 | NTM | 15.4 | 42.3 | 2.746753 |
| ES | 21 | SVIL | 23.0 | 63.1 | 2.743478 |
| AP | 1 | CASQ1 | 29.0 | 79.4 | 2.737931 |
| AP | 1 | FAM72A | 12.5 | 33.9 | 2.712 |
| ES | 14 | RBM26 | 12.7 | 34.3 | 2.700787 |
| AP | 1 | HDAC9 | 17.7 | 46.9 | 2.649718 |
| AP | 3 | ALDH1L1 | 32.3 | 84.2 | 2.606811 |
| AT | 2.2 | KCNK9 | 20.4 | 53.0 | 2.598039 |
| AT | 7.2 | ADRA1A | 13.7 | 35.5 | 2.591241 |
| ES | 17 | CAMKK2 | 13.0 | 33.5 | 2.576923 |
| ES | 17: 18 | MARK3 | 13.5 | 34.3 | 2.540741 |