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. 2020 Jan 6;12(1):543–570. doi: 10.18632/aging.102640

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Copyright © 2020 Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Activation of α7 nAChR attenuates apoptosis induced by Aβ oligomers. (A) The primary hippocampus cell group (Control), (B) the primary hippocampus cells treated with PNU (PNU), (C) the primary hippocampus cell treated with MLA (MLA), (D) the primary hippocampus cell treated with Aβ (Aβ), (E) the primary hippocampus treated with PNU and Aβ (PNU+Aβ), (F) the primary hippocampus treated with MLA and Aβ (MLA+Aβ) and (G) a histogram presenting the apoptotic death rates of the different groups. (C and D) The apoptosis rate of primary neuronal cells treated with MLA and Aβ oligomers was significantly increased, (E) while α7 nAChR attenuated apoptosis induced by Aβ oligomers. Data are presented as the mean ± standard deviation. ^*P<0.05, ^**P<0.01 vs. control group; ^#P<0.05, ^##P<0.01 vs. Aβ group.