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. 2020 Jan 8;12(1):70–79. doi: 10.18632/aging.102585

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Copyright © 2020 Tong et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Elevated MACC1-AS1 expression promoted HCC cell epithelial-mesenchymal transition and invasion. (A) Ectopic MACC1-AS1 expression promoted vimentin, N-cadherin and snail expression and inhibited E-cadherin expression in SMMC7721 cell. (B) The mRNA expression of vimentin, N-cadherin, snail and E-cadherin was detected by qRT-PCR. (C) MACC1-AS1 overexpression induced the cell invasion in SMMC7721 cell. (D) The relative number of invasive cells is shown. (E) MACC1-AS1 overexpression induced the cell invasion in MHCC-97H cell. (F) The relative number of invasive cells is shown. ***p<0.001.