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. 2020 Jan 5;12(1):204–223. doi: 10.18632/aging.102610

Figure 4.

Figure 4

COL4A1 and COL4A2 genomic alterations, correlation, and signaling pathway in HCC (cBioPortal). (A) Heat map showing the genomic alteration types and expression of COL4A1 and COL4A2 in HCC tissues (n=371). The genomic alterations are highlighted in different markers. One column represents one individual. (B) Correlation analysis showing the significant positive correlation between COL4A1 and COL4A2. (C) COL4A1 and COL4A2 shared a bidirectional promoter, which was regulated by the downstream activating element. (D) Network showing the COL4A1/COL4A2 (with a bold border) and their neighboring genes with alteration frequencies >10% in HCC. PTK2 (in darker red) was the most frequently altered neighbor gene (46.4%). The brown connection shows that these genes are involved in the same biological component, such as a complex. The blue connection shows that the first gene causes a state change, such as a phosphorylation change, within the second gene.