Table 1. The most frequently altered neighbor genes of COL4A1 and COL4A2 in HCC(cBioPortal).
| Gene symbol | Amplification | Homozygous deletion | Up-regulation | Down-regulation | Mutation | Total alteration |
| COL4A1 | 3.80% | 0.00% | 5.60% | 0.00% | 2.10% | 11.00% |
| COL4A2 | 3.80% | 0.30% | 4.60% | 0.00% | 1.60% | 9.90% |
| PTK2 | 16.10% | 0.30% | 41.00% | 0.50% | 2.10% | 46.40% |
| ACTN2 | 8.60% | 0.00% | 15.50% | 0.00% | 1.60% | 24.10% |
| THBS3 | 13.70% | 0.00% | 13.70% | 0.00% | 1.60% | 20.10% |
| COL22A1 | 16.40% | 0.00% | 1.10% | 0.00% | 3.20% | 19.30% |
| P4HB | 6.20% | 0.30% | 11.80% | 0.30% | 0.30% | 15.80% |
| ACTG1 | 6.20% | 0.00% | 9.90% | 0.00% | 0.30% | 15.30% |
| LAMB3 | 9.40% | 0.00% | 3.50% | 0.00% | 1.90% | 13.90% |
| ITGA10 | 9.90% | 0.00% | 2.10% | 0.00% | 1.90% | 13.10% |
| LAMC1 | 9.10% | 0.00% | 3.20% | 0.00% | 1.60% | 12.90% |
| LAMC2 | 9.10% | 0.00% | 1.90% | 0.00% | 1.60% | 12.60% |
| ITGB4 | 5.60% | 0.00% | 4.80% | 0.00% | 2.40% | 12.60% |
| PLOD3 | 0.80% | 0.00% | 11.50% | 0.50% | 0.30% | 12.60% |
| COLGALT2 | 9.40% | 0.00% | 0.50% | 0.00% | 1.30% | 11.00% |
| MSR1 | 0.30% | 7.00% | 3.50% | 0.00% | 0.30% | 10.20% |