Table 6. Factors associated with SAA in HHT patients.
| HHT patients with SAA n = 46 | HHT patients without SAA n = 140 |
Univariate | Multivariate | OR (95% CI) | |
|---|---|---|---|---|---|
| Gender (female) | 29 (63%) | 60 (43%) | 0.017 | 0.04 | 2.12 (1.03–4.50) |
| Age (years) | 57 ± 14 | 43 ± 18 | <0.0001 | 0.0003 | 1.04 (1.02–1.06) |
| Type of mutation A/E | 27A/17E | 61A/62E | 0.18 | ||
| Pulmonary Involvement | 31 (37%) | 82 (58%) | 0.29 | ||
| Hepatic Involvement | 33 (72%) | 97 (69%) | 0.75 | ||
| Splenic Involvement | 9 (19%) | 17 (12%) | 0.21 | ||
| Pancreatic Involvement | 25 (54%) | 39 (28%) | 0.001 | 0.04 | 2.13 (1.01–4.49) |
| Maximal Size of the Spleen (mm)* | 10.5 ± 1.4 | 10.5 ± 1.7 | 0.99 | ||
| Maximal Size of the Liver (mm)* | 16.5 ± 1.7 | 16.7± 2.1 | 0.41 |
OR = Odd Ratio, CI = Confidence Interval
A = ACVRL1, E = Endoglin
SAA = Splenic Artery Aneurysm, HHT = Hereditary Hemorrhagic Telangiectasia
*Organ size measured by the vertical long axis in a coronal plane