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. 2019 Aug 23;36(2):153–164. doi: 10.1007/s12264-019-00422-4

Fig. 5.

Fig. 5

Ketamine administered 22 h after fear conditioning decreases fear generalization. A Experimental design. B Injection of ketamine 22 h after fear conditioning showed a significantly lower fear response to the CS– tone than the saline group. C Ketamine-injected mice expressed lower levels of the index of behavioral generalization (IBG) than the saline group. D, E The effect of ketamine remained significant for at least 2 weeks. n = 8 mice/group; mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001. Test 1, 2 h after ketamine injection; Test 2, 1 week after ketamine injection; Test 3, 2 weeks after ketamine injection.