Fig. 1.

The structure of DARPins. A – the structure of the consensus ankyrin repeat; the constant part is shown in gray; the variable regions are shown in red. B – the structure of a DARPin molecule. Two or three binding motifs form the binding surface through variable amino acids (shown in red); the hydrophobic regions are shielded by the C-cap and N-cap. C – 3D structure of a DARPin molecule, the variable amino acids are shown in red