Fig. 2.

Schematic representation of the HLA locus on human chromosome 6. The HLA region is located on the short arm of chromosome 6 from 6p21.1 to p21.3 and is shown with a red stripe. The length of class II (red), class III (blue), and class I (green) genes (from the centromeric to the telomeric end) is shown. The class II region includes genes for the α and β chains of the MHC class II molecules HLA-DR, HLA-DP and HLA-DQ. In addition, the genes encoding the DMα and DMβ chains, as well as the genes encoding the α and β chains of the DO molecule (DOα and DOβ, respectively), are also located in the MHC class II region