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. 2020 Jan 8;9:e50109. doi: 10.7554/eLife.50109

Figure 8. Model for roles of TFIID and SAGA and two different gene classes.

Figure 8.

Of the ~83% of yeast protein-coding genes analyzed in this study (4900 genes), the number of genes in each class is shown. Expression of genes in the TFIID set is strongly TFIID-dependent with little or no change after rapid SAGA depletion. TFIID and SAGA both contribute to expression of the coactivator-redundant genes where these factors have substantial overlapping function as revealed by rapid depletion experiments. Prior work suggests that these effects are due in part to the TBP-promoter DNA loading functions of TFIID and SAGA. Expression of nearly all genes is dependent on a separate function of SAGA, revealed by deletions in SAGA subunit genes, that is strongly linked to chromatin modifications that change slowly after rapid SAGA depletion.