. Author manuscript; available in PMC: 2020 Jan 23.

Published in final edited form as: Int J Dev Biol. 2019 Jan 1;63(8-9-10):359–369. doi: 10.1387/ijdb.190108ps

Table 1. Signal transduction proteins in uni- and multicellular Amoebozoa.

Category	Dictyostelium discoideum	Protostelium aurantium	Physarum polycephalum	Acanthamoeba castellanii

G-protein coupled receptors	55	17	146	35
Heterotrimeric G-proteins
Alpha	12	9	26	6
Beta	1	1	1	n.d.
Gamma	1	1	1	n.d.
Histidine kinases/phosphatases	16	71	51	48
Cyclic nucleotide signaling
Adenylate/guanylate cyclases	5	52	64	67
cNMP binding domains	5	27	28	7
cNMP phosphodiesterases	7	16	11	10
Protein kinases
All (S/T, S/T/Y, Y)	295	827	447	377
Sensor tyrosine kinases (Y)	0	167	4	21
SH2 domain proteins	15	85	18	48