Table 1.
Clinical characteristics
| CHIP-mutation negative | CHIP-mutation positive | Total | |||||
|---|---|---|---|---|---|---|---|
| N | % | N | % | P | N | % | |
| Total | 380 | 63.97 | 214 | 36.03 | 594 | 100.00 | |
| Men | 127 | 33.42 | 69 | 32.24 | .769 | 196 | 33.00 |
| Age at blood collection, y | |||||||
| 73-75 | 72 | 18.95 | 29 | 13.55 | <.001 | 101 | 17.00 |
| 75-80 | 205 | 53.95 | 101 | 47.20 | 306 | 51.52 | |
| 80-85 | 82 | 21.58 | 47 | 21.96 | 129 | 21.72 | |
| 85-93 | 21 | 5.53 | 37 | 17.29 | 58 | 9.76 | |
| Zygosity | |||||||
| MZ | 155 | 40.79 | 101 | 47.20 | .130 | 256 | 43.10 |
| DZ | 225 | 59.21 | 113 | 52.80 | 338 | 56.90 | |
| Tobacco consumption (pack-years) | |||||||
| 0 | 146 | 38.42 | 79 | 36.92 | .815 | 225 | 37.88 |
| 1st tertile (1-8.55) | 746 | 20.00 | 40 | 18.69 | 116 | 19.53 | |
| 2nd tertile (8.55-25) | 77 | 20.26 | 46 | 21.50 | 123 | 20.71 | |
| 3rd tertile (25+) | 65 | 17.11 | 43 | 20.09 | 108 | 18.18 | |
| Missing | 16 | 4.21 | 6 | 2.80 | 22 | 3.70 | |
| Dead prior to August 2018 | 359 | 94.47 | 210 | 98.13 | .033 | 569 | 95.79 |
We included 299 twin pairs and sequenced peripheral blood DNA from all twins. Four twins had low-quality DNA and were excluded from the study, and 594 remaining twins were included in the study. In August 2018, 96% of the cohort had died, and follow-up was available for all twins. Only 38% of the cohort never smoked; the smokers were divided into tertiles according to tobacco consumption for survival analysis.