Figure 2.

GNX enhances axonal myelination 7 days post–lysolecithin‐induced demyelination in the corpus callosum. (A) and (B) are TEM images of the demyelinated corpora callosa of vehicle‐treated and GNX‐treated rats, respectively. Yellow arrowheads indicate myelinated axons, while green arrows indicate unmyelinated ones. (C,D,E) Summary bar graphs showing that GNX treatment significantly reduced the g‐ratio compared to vehicle treatment (Lyso‐Vehicle: n = 3, Lyso‐GNX: n = 3, P < .05), resulted in a significantly lower number of unmyelinated axons compared to vehicle‐treated rats (P < .05), and significantly increased the number of myelinated axons compared to vehicle treatment (P < .05), respectively. Scale bar = 1 µm