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. 2019 Nov 20;80(1):33–46. doi: 10.1007/s40265-019-01226-6

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Timeline of the development of costimulation blockade. The costimulation blockade drugs that are currently used or tested in kidney transplant recipients are shown in black, whereas the costimulation blockade drugs that are no longer being used or have not developed for kidney transplantation are shown in grey. EMA European Medicines Agency, FDA United States Food and Drug Administration, FR104 pegylated monoclonal antibody fragment antagonist of CD28, TGN1412 CD28 humanized antibody