Table 2.
MIC values of the SCPs, PMB, and control peptides.
| Strains | MIC | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A6 | G6 | N6 | PMB | LBP14 | LBPN6 | N6CK | A6CK | G6CK | ||||||||||
| μg per ml | μM | μg per ml | μM | μg per ml | μM | μg per ml | μM | μg per ml | μM | μg per ml | μM | μg per ml | μM | μg per ml | μM | μg per ml | μM | |
| Gram-negative bacteria | ||||||||||||||||||
| Escherichia coli CVCC195a | 8 | 1.5 | 4 | 0.88 | 1 | 0.4 | 1 | 0.84 | 8 | 4.53 | 64 | 15.2 | >64 | >25.8 | 64 | 12.4 | 32 | 7.1 |
| E. coli CVCC1515a | 16 | 3 | 16 | 3.52 | 1 | 0.4 | 1 | 0.84 | 8 | 4.53 | 32 | 7.6 | >64 | >25.8 | >64 | >12.4 | 16 | 3.5 |
| Salmonella typhimurium ATCC14028c | 8 | 1.5 | 4 | 0.88 | 4 | 1.6 | 2 | 1.68 | 16 | 9.06 | 32 | 7.6 | >64 | >25.8 | >64 | >12.4 | 32 | 7.1 |
| S. pullorum CVCC533a | 16 | 3 | 16 | 3.52 | 2 | 0.8 | 1 | 0.84 | 32 | 18.1 | 32 | 7.6 | >64 | >25.8 | >64 | >12.4 | >64 | >14.2 |
| S. pullorum CVCC1809a | 8 | 1.5 | 8 | 1.76 | 2 | 0.8 | 1 | 0.84 | 16 | 9.06 | 32 | 7.6 | >64 | >25.8 | >64 | >12.4 | 32 | 7.1 |
| Pseudomonas aeruginosa CICC10419b | >64 | >12 | 16 | 3.52 | 16 | 6.4 | >64 | >53.76 | 64 | 36.2 | 64 | 15.2 | >64 | >25.8 | >64 | >12.4 | >64 | >14.2 |
| Gram-positive bacteria | ||||||||||||||||||
| Staphylococcus aureus ATCC43300c | >64 | >12 | 16 | 3.52 | 16 | 6.4 | >64 | >53.76 | 64 | 36.2 | 64 | 15.2 | >64 | >25.8 | >64 | >12.4 | >64 | >14.2 |
| Enterococcus faecalis CVCC3936a | 32 | 6 | 16 | 3.52 | 32 | 12.8 | >64 | >53.76 | 32 | 18.1 | 8 | 1.9 | >64 | >25.8 | >64 | >12.4 | 16 | 3.5 |
| Streptococcus suis CVCC606a | 32 | 6 | 16 | 3.52 | 64 | 25.6 | >64 | >53.76 | >64 | >36.2 | 32 | 7.6 | >64 | >25.8 | >64 | >12.4 | >64 | >14.2 |
| Bacillus subtilis ATCC6633c | 8 | 1.5 | 8 | 1.76 | 1 | 0.4 | 0.5 | 0.42 | 32 | 18.1 | 16 | 3.8 | >64 | >25.8 | 16 | 3.1 | 4 | 0.9 |
| Listeria ivanovii ATCC19119c | >64 | >12 | >64 | >14.08 | >64 | >25.6 | >64 | >53.76 | 8 | 4.53 | 8 | 1.9 | >64 | >25.8 | >64 | >12.4 | 8 | 1.8 |
| Fungi | ||||||||||||||||||
| Candida albicans CGMCC2.2411d | >64 | >12 | >64 | >14.08 | >64 | >25.6 | >64 | >53.76 | >64 | >36.2 | >64 | >15.2 | >64 | >25.8 | >64 | >12.4 | >64 | >14.2 |
Data are representative of three independent experiments. The MDR E. coli CVCC195 strain is resistant to tetracyclines (doxycycline), penicillins (benzocillin and penicillin), lincosamides (lincomycin and clindamycin), glycopeptides (vancomycin), amphenicols (chloramphenicol), macrolipids (erythromycin), aminoglycosides (amikacin, streptomycin and gentamicin) and sulfonamides (sulfamethoxazole), respectively.
PMB: polymyxin B; NN: no detection, N6CK: N6 scramble control, A6CK: A6 scramble control, G6CK: G6 scramble control.
aChina Veterinary Culture Collection Center (CVCC).
bChina Center of Industrial Culture Collection (CICC).
cAmerican Type Culture Collection (ATCC).
dChina General Microbiological Culture Collection Center (CGMCC).