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. 2020 Jan 23;11:448. doi: 10.1038/s41467-019-14208-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a A single-molecule emission record, as in Fig. 1c, for a different DNA spot location. Gray, teal, and purple highlight time intervals of high RNAP⁵⁴⁹ fluorescence before detection of transcript probe and post-termination intervals of fluctuating and low fluorescence, respectively. b Mean squared displacement (MSD) of RNAP⁵⁴⁹ position on DNA during the teal and purple intervals in (a). Linear fits to the first ten points of each MSD curve yield the effective diffusion coefficients over 10 s intervals, D. c Normalized histogram of D values measured separately for every 50 s window in n = 41 recordings of RNAP⁵⁴⁹ retained on DNA after termination (13,522 windows total).