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. 2020 Jan 23;10:1059. doi: 10.1038/s41598-020-57741-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increased “naïve” but decreased “unswitched” and “isotype-switched” memory peripheral blood B cells in sarcoidosis patients. Scatter plots (a–d) showing the percentages “naïve” cells (IgD + CD27−) and three types of memory cells – “unswitched” memory cells (IgD + CD27+), “class-switched” memory cells (IgD − CD27+) and so-called “double-negative” memory cells (IgD − CD27−), respectively, in the peripheral blood samples for sarcoidosis patients (n = 37, black circles, SP) and healthy control subjects (n = 35, white circles, HC). Numbers represent the percentage of the indicated B cell subset among total CD19+ B cell population. Each dot represents individual subjects, and horizontal bars represent the group medians and quartile ranges (Med (Q25; Q75). Statistical analysis was performed with the Mann-Whitney U test (*** – p < 0.001; n.s. – no significance).