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. 2020 Jan 23;11:450. doi: 10.1038/s41467-019-14200-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a A DNA template contains two transcription units with a roadblock (purple hexagon) between them. Transcripts from the downstream unit have a probing target (brown box). b Three possible courses are reinitiation on the downstream unit after TS termination, no reinitiation after TS termination, and readthrough at TS with continued downstream transcription. c Three types of fluorescence time traces were observed; Cy3 vanishing with Cy5 probing (type 1), Cy3 vanishing without Cy5 probing (type 2), and Cy3 nonvanishing with Cy5 probing (type 3).