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. 2020 Jan 23;10:1046. doi: 10.1038/s41598-020-57854-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Knockdown of ITCH causes the upregulation of TP73 (A) and induces apoptosis of Kelly cells upon irradiation. (A) Western blot showing silencing of ITCH protein and upregulation of TP73 after transfection of ITCH siRNA in Kelly cells. 1, 3, 5 and 7 are samples transfected with ITCH siRNA; 2, 4, 6 and 8 are samples transfected with irrelevant siRNA. D1, D2, D3 and D6 suggested days after transfection. (B) Apoptotic cells after irradiation of Kelly cells which have been transfected with ITCH siRNA (b) and irrelevant siRNA (a). Quantification of percentage of SubG1 cells within each treatment group (c).