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. 2020 Jan 23;11(1):58. doi: 10.1038/s41419-020-2231-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b The liver weight/body weight ratio (a), and serum ALT and AST levels (b) of TCTP^+/+ and TCTP^+/− mice were measured at the indicated time points during LR. c Representative IHC staining of Ki67 (brown) on liver sections obtained from TCTP^+/+ and TCTP^+/− mice at the indicated time points of LR; Scale bars: 200 μm. d The number of Ki67-positive hepatocytes was counted and used as an indicator to compare with the regenerative ability of livers obtained from TCTP^+/+ and TCTP^+/− mice. e The RT-PCR analysis for the mRNA expression level of, CCND1, P21, P27, CCNA2, IL-6, TNF-α and HGF in livers obtained from TCTP^+/+ and TCTP^+/− mice at the indicated time points of LR. The results were presented as mean ± standard deviation (SD). n = 5. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 vs. control (Two-way ANOVA followed by Tukey’s test).