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. 2020 Jan 23;10:1037. doi: 10.1038/s41598-020-58040-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Complex trait clusters share several key enriched molecular pathways. (a) A histogram of numbers of enrichments per each gene set from the MSigDB collections. Upper panel, number of enriched phenotypes and enriched clusters; lower panel, number of clusters showing significant enrichment of 2 or more phenotypes. (b) A circle-map representation of LSEA results for common (shared by 2 or more phenotypes) associated SNPs for each multi-phenotype cluster. Only gene sets with shared enriched phenotypes in 2 or more clusters are shown (only top 100 enrichments for each cluster were chosen). (c,d) Curated gene sets (c) and GO molecular function terms (d) with the highest number of enriched clusters based on LSEA analysis. Top-20 hits are shown in each case.