Fig. 2.

Two hypothetical types of cerebellar ocular motor reserve systems. a In high-risk cerebellar reserve, the neural substrate for the cerebellar reserve reside in proximity to the primary region. In such system, the lesion of primary substrate is also likely to affect parts of the reserve. As a result, there is poor reversibility of the lost motor function (or motor abnormality). In contrast, in low-risk cerebellar reserve, b the neural substrate for reserve is discretely located. In this system, the lesion to primary system does not affect the reserve, and there is an opportunity to compensate and reverse the motor function by upregulation of the reserve system