Fig. 5.

Lesion- and environmental enrichment-induced modifications of synaptogenesis. Effects of hemicerebellectomy (HCb) in standard reared animals (on the left) and in enriched animals (on the right) on Purkinje cell dendritic spines. The changes occurring in density and size of Purkinje cell spines of vermis and hemisphere are reported. Upper histograms show mean spine density in Purkinje cell distal dendrites. Lower histograms show mean spine area in Purkinje cell distal dendrites. Asterisks indicate significant differences (Tukey’s post hoc comparisons [20]) between groups: *p < 0.05; ***p < 0.0005. Data are shown as mean ± S.E.M. HCbed hemicerebellectomized