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. 2020 Jan 23;11(1):51. doi: 10.1038/s41419-020-2253-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Volcano plot representation of differential gene expression analysis in BAT of 6-month-old WT (upper panel) and KIKO mice (lower panel) exposed to cold for 12 h. Light blue and red squares mark the genes with significantly decreased or increased expression, respectively (p < 0.05, n = 3). b, c Biological processes b, KEGG and Wiki pathways c significantly up-regulated in BAT of WT (left panels) and KIKO mice (right panels) upon cold exposure determined through ClueGo plugin of Cytoscape v3.7 platform (Benjamini-corrected p-values < 0.05). d Comparative analysis of significantly up-regulated biological processes (p < 0.05) in WT mice and KIKO mice determined through Funrich v3.0. e Heatmap showing representative genes significantly up-regulated (p < 0.05) in WT mice compared to KIKO mice.