Figure 4.

Markers of P2Y₁₂ Signaling

(A) Adenosine diphosphate (ADP)-induced maximal platelet aggregation (MPA%) measured by light transmittance aggregometry (LTA). The p values represent comparisons between the 2 groups at each time point. Error bars indicate SD. Intragroup comparisons for non-DM: Baseline versus DAPT + vorapaxar: p = 0.166. Baseline versus clopidogrel + vorapaxar: p = 0.811. DAPT + vorapaxar versus clopidogrel + vorapaxar: p = 0.269. Intragroup comparisons for DM: Baseline versus DAPT + vorapaxar: p = 0.837. Baseline versus clopidogrel + vorapaxar: mean difference = 12; 95% CI: 5 to 20; p = 0.002. DAPT + vorapaxar versus clopidogrel + vorapaxar: mean difference = 13; 95% CI: 5 to 20; p = 0.002. (B) Platelet reactivity index (PRI) measured by vasodilator-stimulated phosphoprotein (VASP). The p values represent comparisons between the 2 groups at each time point. Error bars indicate SD. Intragroup comparisons for non-DM: Baseline versus DAPT + vorapaxar: p = 0.063. Baseline versus clopidogrel + vorapaxar: p = 0.067. DAPT + vorapaxar versus clopidogrel + vorapaxar: p = 0.959. Intragroup comparisons for DM: Baseline versus DAPT + vorapaxar: p = 0.296. Baseline versus clopidogrel + vorapaxar: p = 0.142. DAPT + vorapaxar versus clopidogrel + vorapaxar: p = 0.398. Abbreviations as in Figure 1.