Figure 5.

Markers Sensitive to Cyclooxygenase-1 Blockade

(A) Arachidonic acid (AA)-induced maximal platelet aggregation (MPA%) measured by light transmittance aggregometry (LTA). The p values represent comparisons between the 2 groups at each time point. Error bars indicate SD. Intragroup comparisons for non-DM: Baseline versus DAPT + vorapaxar: mean difference = 2; 95% CI: −10 to 15; p = 0.734. Baseline versus clopidogrel + vorapaxar: mean difference = 42; 95% CI: 26 to 58; p < 0.001. DAPT + vorapaxar versus clopidogrel + vorapaxar: mean difference = 44; 95% CI: 28 to 60; p < 0.001. Intragroup comparisons for DM: Baseline versus DAPT + vorapaxar: mean difference = 9; 95% CI: −2 to 21; p = 0.108. Baseline versus clopidogrel + vorapaxar: mean difference = 40; 95% CI: 25 to 54; p < 0.001. DAPT + vorapaxar versus clopidogrel + vorapaxar: mean difference = 49; 95% CI: 36 to 63; p < 0.001. (B) Serum thromboxane B₂ (TXB₂). The p values represent comparisons between the 2 groups at each time point. Error bars indicate SD. Intragroup comparisons for non-DM: Baseline versus DAPT + vorapaxar: p = 0.545. Baseline versus clopidogrel + vorapaxar: p < 0.001. DAPT + vorapaxar versus clopidogrel + vorapaxar: p < 0.001. Intragroup comparisons for DM: Baseline versus DAPT + vorapaxar: p = 0.671. Baseline versus clopidogrel + vorapaxar: p < 0.001. DAPT + vorapaxar versus clopidogrel + vorapaxar: p < 0.001. Abbreviations as in Figure 1.