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. 2020 Jan 17;10:1557. doi: 10.3389/fphys.2019.01557

FIGURE 5.

FIGURE 5

On top, representative images of western blot and, at the bottom, densitometric analysis of the expression of (A) caspase-1 and pro-caspase-1 and (B) IL-1β and pro-IL-1β in endothelial cells primed with lipopolysaccharide (LPS) and incubated with vehicle (white squares) and mitochondrial DNA from control (cmDNA, white circles) and diabetic (dmDNA, black circles) mice. (C) Cumulative concentration-response curves to acetylcholine (ACh), endothelium-dependent vasodilator, in resistance mesenteric arteries from C57BL/6 incubated with vehicle (white circles) or mitochondrial DNA from diabetic mice (dmDNA, black circles) in the presence of vehicle (white triangles) or a NLRP3 inhibitor (MCC950, black triangles). Each point/column represents the mean ±SEM. ∗P < 0.05 vs. vehicle. N = 3–5, one-way ANOVA (A–C).