Fig. 2.

Effect of LY344864 on mtDNA and protein expression 3 days post-SCI. Mice were subjected to moderate SCI using an 80 kdyn force-controlled impactor-induced contusion model followed by daily administration of vehicle or LY344864 (2 mg/kg i.p.) beginning 1 h postinjury and continuing for 3 days. The injury and peri-injury sties were extracted and analyzed for mtDNA content (A). The injury site was also analyzed for mitochondrial protein expression (B). Data represent five mice per group and are expressed as mean ± S.E.M. *P < 0.05 compared with Sham and #P < 0.05 compared with SCI + Vehicle by one-way ANOVA followed by Tukey’s post hoc test.