Fig. 4.
Effect of LY344864 on recovery post-SCI in C57BL/6J WT and 5-HT1F KO mice. Mice were subjected to moderate SCI using an 80 kdyn force-controlled impactor-induced contusion model followed by daily administration of vehicle or LY344864 (2 mg/kg i.p.) beginning 1 h post-SCI (A and B). Locomotor function was assessed using the Basso Mouse scale beginning 24 h after injury and continuing every alternate day. Mice were also subjected to moderate SCI using an 80 kdyn force-controlled impactor-induced contusion model followed by daily administration of vehicle or LY344864 (2 mg/kg i.p.) beginning 8 h postinjury (C). Data are representative of eight mice per sham group and 10 mice per SCI group and are expressed as mean ± S.E.M. Significance between sham and injured animals is not represented on graph for simplicity. *P < 0.05 compared with SCI + Vehicle and #P < 0.05 compared with day 1 by two-way ANOVA with repeated measures followed by Tukey’s post hoc test.