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Schematic diagram of the HSPG perlecan and HS. The different domains of perlecan are depicted by roman numerals. The insert depicts a schematic of HS represented by the repeating disaccharide of N-acetyl glucosamine and glucuronic acid (or iduronic acid) and sulfate moieties that can occur. Enzymatic modification of HS can occur via heparanase cleavage, resulting in smaller molecular weight fragments, or cleaving the 6-O sulfate on glucosamine via sulfatase.
