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Production of cytolytic polyenes by TR1341. LC-MS analysis of the TR1341 extract of secondary metabolites: Filipin III (A) and fungichromin (C) peaks and corresponding MS analyses (B,D). Disruption of the filipin III and fungichromin production in the TR1341ΔFIL2 mutant: (E) wt chromatogram, (F) mutant chromatogram. The absorption spectra of compounds correspond to the standards of both polyenes – 5 conjugated double bonds (Castanho et al., 1992) (G).
