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. 2020 Jan 17;10:3028. doi: 10.3389/fmicb.2019.03028

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Copyright © 2020 Herbrík, Corretto, Chroňáková, Langhansová, Petrásková, Hrdý, Čihák, Krištůfek, Bobek, Petříček and Petříčková.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of TR1341 extracts on THP-1 human macrophages. Viability of the cells indicated by gray rectangles (top axis scale), pro-inflammatory activation of the cells measured as IL-1β release indicated by black rectangles (bottom axis). In all the assays THP-1 were activated by LPS. (A) Standard fermentation in GYM media – effect of extract dilution (dilution indicated on the Y axis). Control = cells + LPS + DMSO. (B) Effect of preculture of TR1341 with THP-1 prior to fermentation on production of pro-inflammatory and cytotoxic compounds. Control as above, extracts diluted 1:5,000.