TABLE 1.

Putative hemolysin genes in TR1341 genome and their homologs in S. coelicolor A3(2) genome (NC_003888.3).

TR1341 ORF	S. coelicolor homolog	Similar to	Surrounding genes relevant to putative survival in the host
FSY75_36865	SCO1782	Bifunctional tRNA methyl-transferase/TlyA hemolysin of Mycobacterium tuberculosis (AQO55200.1) and Brachyspira (former Treponema) hyodysenteriae (APP13931.1)	Fe3+-siderophore ABC-type transporter (Rahman et al., 2010; Forrellad et al., 2013; Rahman et al., 2015)
FSY75_17865	SCO2534	HlyC/CorC family magnesium and cobalt efflux protein – TlyC family: hemolysin C of Brachyspira hyodysenteriae (ACN83901.1) and Co2+-resistance protein CorC of Salmonella typhimurium (TKE78380.1), TlyC hemolysin of Rickettsia prowazekii (CAA72456.1)	Adenosine deaminase (Lee and Yilmaz, 2018) Methalo beta-lactamase (Somboro et al., 2018) Heat shock-inducible repressor and DnaJ chaperone (Forrellad et al., 2013)
FSY75_04245	SCO3882	HylA/YidD, Aeromonas hydrophila β-hemolysin (WP_011707926.1)	Thioredoxin, thioredoxin reductase (May et al., 2019)
FSY75_26430	SCO4978	YqfA family hemolysin III family, e.g., Escherichia coli (ANK03204.1)	Aspartate aminotransferase (Wang et al., 2016) Phosphoenolypyruvate carboxykinase (Forrellad et al., 2013) Thymidylate kinase (Challacombe et al., 2014)

Gene Bank Accession numbers of homologous proteins given in brackets. The last column of the table shows genes that are encoded in the close vicinity of the putative hemolysin genes and may play roles in the bacteria survival in the host tissue. Protein family names are shown in bold.