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. 2020 Jan 17;10:1561. doi: 10.3389/fphar.2019.01561

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Copyright © 2020 Jiang, Xiao, Fu, Tang, Lertnimitphun, Kim, Zheng, Tan, Lu and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gaudichaudione H (GH) inhibited cytokines production and inflammatory genes messenger RNA (mRNA) expression in colon of dextran sodium sulfate (DSS)-induced mice. Colons from mice were removed at the end of experiment, and finally lysed. Interleukin-6 (IL-6) (A) and tumor necrosis factor-α (TNF-α) (B) production in the supernatants were assayed using ELISA. The data are the means ± SEM, n = 7. Total RNA from colon tissues was isolated using TRIzol reagent, the mRNA expressions of IL-6 (C), TNF-α (D), inducible nitric oxide synthase (iNOS) (E), and cyclooxygenase-2 (COX-2) (F) were detected using real-time PCR (RT-PCR). The data are the means ± SEM, n = 8. ^### p < 0.001 compared with control, *p < 0.05, **p < 0.01, ***p < 0.001 compared with 3.5% DSS.