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. 2020 Jan 17;9:1541. doi: 10.3389/fonc.2019.01541

Table 2.

Mortality observed in C3H/HeJ mice after a single acute dose of L-selenomethionine (SeMet) or SeNP.

Days Number of deaths at various doses of SeMet
5 mg Se/kg 7.5 mg Se/kg 10 mg Se/kg 15 mg Se/kg 20 mg Se/kg
1 0 0 1 2 5
2 0 1 2 1 0
3 0 0 0 0 0
4 0 0 0 0 0
5 0 0 0 0 0
6 0 0 0 0 0
7 0 0 0 0 0
8 0 0 0 0 0
9 0 0 0 0 0
10 0 0 0 0 0
11 0 0 0 0 0
12 0 0 0 0 0
13 0 0 0 0 0
14 0 0 0 0 0
Days Number of deaths at various doses of SeNPs
10 mg Se/kg 20 mg Se/kg 50 mg Se/kg 70 mg Se/kg 110 mg Se/kg
1 0 0 0 0 0
2 0 0 0 0 0
3 0 0 0 0 0
4 0 0 0 0 0
5 0 0 0 0 0
6 0 0 0 0 0
7 0 0 0 0 0
8 0 0 0 0 0
9 0 0 0 0 0
10 0 0 0 0 0
11 0 0 0 0 0
12 0 0 0 0 0
13 0 0 0 0 0
14 0 0 0 0 0

The lethal effect was observed only in the initial days of the SeMet treatment and no death was observed after day 2. Again, no mortality was observed in the group of SeNP treated mice.