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. 2020 Jan 17;10:2971. doi: 10.3389/fimmu.2019.02971

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Copyright © 2020 De Picker, Fransen, Coppens, Timmers, de Boer, Oberacher, Fuchs, Verkerk, Sabbe and Morrens.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mean concentration of each biological marker per cohort over time. (A–C) Trait markers for psychotic illness: KA/Kyn, KA, CRP. (D–I) State markers for the acute psychotic state: IL6, IL8, TNFα, QA, 3HK, Nitrite. (J,K) Trait ánd state markers for psychotic illness and the acute psychotic state: IL1RA, CCL2/MCP1. Error bars represent mean ± SE. Dotted lines indicate control subjects, full lines patients. “UMP” (unmedicated psychosis) represents the first blood sampling in patients; “Psychosis” represents the second blood sampling in patients and the first blood sampling in controls; “Follow-up” represents the last timepoint in patients and controls.