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. 2019 Dec 17;6(6):ENEURO.0453-18.2019. doi: 10.1523/ENEURO.0453-18.2019

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Copyright © 2019 Andersen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 3. — Striatal neurodegenerative processes and α-synuclein phosphorylation are not halted by chronic LRRK2 inhibition. A, Western blot analysis of tyrosine hydroxylase (TH) and hwt α-synuclein (hwt α-syn; left) as well as phosphorylation of α-synuclein-S129 (α-syn pS129; right). i = ipsilateral to the viral injection; c = contralateral to the viral injection. B, Quantification of TH expression from ipsilateral and contralateral striatum normalized to STEP46 and presented as percentage of contralateral striatum shows a significant loss of TH expression in α-syn overexpressing rats in both treatment groups (one-way ANOVA, p < 0.001). C, The expression level of hwt α-synuclein normalized to STEP46 is not significantly different between groups (unpaired t test, p = 0.22). D, The α-synuclein-S129 phosphorylation from ipsilateral and contralateral striatum normalized to STEP46 and presented as percentage of contralateral striatum is not significantly different between groups (one-way ANOVA, p = 0.076). CTRL veh, CTRL PFE-360 and α-syn veh; N = 5, α-syn PFE-360 N = 6. Tukey’s multiple comparison is represented by the lines; ***p < 0.001.